This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The current LAMMP 3-D image systems have great ability to non-invasively explore the structural information of biological specimens. However, the lack of native chemical signature makes it difficult to identify the targets non-invasively. On the other hand, Raman spectroscopy provides abundant chemical information for identification and discrimination, nevertheless, the nature of low Raman cross section in common biological sample has limited its application in 3D imaging. In this proposed development, a confocal Raman microscope system will be introduced into the existing CATS so that the new system will provide the ability of point-to-point chemical and biological identification on the background of 3-D structural imaging. This additional information is expected to provide important evidence for the understanding and interpretation of the structural image.
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