This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Imaging in Engineered Tissue (IMINENT) and the 'Photon Forum' are specialized lectures held monthly throughout the year. These two intensely technical lecture series are designed to encourage collaboration and dissemination. Imaging in Engineered Tissue (IMINENT ) was established in February 2006, 9 meetings were held last year. This is a joint seminar that encourages collaboration with other labs on campus. Participants come from Biomedical Engineering (Steve George), Chemical Engineering and Materials Science (Andrew Putnam), and the Laboratory for Fluorescence Dynamics (Enrico Gratton). The meeting topics are listed below; Variations in second harmonic and two photon fluorescence signal from collagen gels due to changes in polymerization conditions.' Christopher Raub (George lab).Mapping dermal structural assembly in normal and pathological connective tissues with intrinsic signal multiphoton optical microscopy. Dr. Julia Lyubovitsky (Tromberg lab)'Proteolytically Mediated Invasion and Differentiation within Fibrin-based Matrices.' Cyrus Ghajar (Putnam lab)MPM/OCM in engineered tissues studies. Dr. Shuo Tang (Tromberg lab)'New methods for quantitatively characterizing engineered tissues using backscattering spectroscopy' Dr. Pedro Quinto-Su (Venugopalan lab) 'Modeling Wound Healing in a Novel Skin-Equivalent Tissue Construct, Using Multiphoton Microscopy' Ryan Lim (Tromberg lab)Prevascularized Implantable Tissue Xiaofang Chen (George lab).Biomedical Engineering Soc. Conference update Chris Raub (George lab).Dynamics of Cell Migration for cells embedded in Collagen using a multimodal platform of Optical Coherence Tomography, Multi-Photon excitation and Second Harmonic Generation Dr. Kandice Tanner (Gratton lab)The 'Photon Forum' consists of intensive technical lectures by LAMMP scientists with substantial feedback and discussion from LAMMP collaborators. Average attendance is approximately 40 people for 9 lectures. This years topics included:Towards functional optical imaging in layered tissues using modulated imagingLong term study of dorsal skinfold model for microvasculature therapiesModel based curve fitting vs dumb correlation: Pros and cons of model driven and data driven approaches in visual reflectance spectroscopy and IR threshold energy diagnosticsLooking at biology with CARSDevelopment of a Laser Microbeam/Microscope Platform for Rapid Single Cell BioanalyticsOptical Intrinsic Signal Imaging, New Vantage'Modeling and Computation at BLI'3-D Optical Coherence Tomography Imaging of Degenerative Joint Cartilage'Use of C# Programming Language for Modulate Imaging'

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001192-28
Application #
7597870
Study Section
Special Emphasis Panel (ZRG1-SSS-X (40))
Project Start
2007-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
28
Fiscal Year
2007
Total Cost
$2,023
Indirect Cost
Name
University of California Irvine
Department
Physiology
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Paugh, Jerry R; Alfonso-Garcia, Alba; Nguyen, Andrew Loc et al. (2018) Characterization of expressed human meibum using hyperspectral stimulated Raman scattering microscopy. Ocul Surf :
Verdel, Nina; Lentsch, Griffin; Balu, Mihaela et al. (2018) Noninvasive assessment of skin structure by combined photothermal radiometry and optical spectroscopy: coregistration with multiphoton microscopy. Appl Opt 57:D117-D122
Friedman, Jacob E; Dobrinskikh, Evgenia; Alfonso-Garcia, Alba et al. (2018) Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun 2:313-328
Kennedy, Gordon T; Lentsch, Griffin R; Trieu, Brandon et al. (2017) Solid tissue simulating phantoms having absorption at 970 nm for diffuse optics. J Biomed Opt 22:76013
Takesh, Thair; Sargsyan, Anik; Lee, Matthew et al. (2017) Evaluating the Whitening and Microstructural Effects of a Novel Whitening Strip on Porcelain and Composite Dental Materials. Dentistry (Sunnyvale) 7:
Jonscher, Karen R; Stewart, Michael S; Alfonso-Garcia, Alba et al. (2017) Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice. FASEB J 31:1434-1448
Alfonso-García, Alba; Paugh, Jerry; Farid, Marjan et al. (2017) A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum. J Raman Spectrosc 48:803-812
Takesh, Thair; Sargsyan, Anik; Anbarani, Afarin et al. (2017) Effects of a Novel Whitening Formulation on Dental Enamel. Dentistry (Sunnyvale) 7:
Alfonso-García, Alba; Smith, Tim D; Datta, Rupsa et al. (2016) Label-free identification of macrophage phenotype by fluorescence lifetime imaging microscopy. J Biomed Opt 21:46005
Prince, Richard C; Frontiera, Renee R; Potma, Eric O (2016) Stimulated Raman Scattering: From Bulk to Nano. Chem Rev :

Showing the most recent 10 out of 663 publications