This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We will characterize bone tissue in-vivo by measuring optical properties using a system developed at the LAMMP that combines broad band near infrared spectroscopy and frequency domain photon migration (SS-FDPM) [1]. Investigations performed in various tissue systems using similar apparatus have uncovered information related to physiologic function that has not been accessible by other means [2-4]. The studies proposed herein will focus on elucidating the relationships between changes in bone density and bone optical properties that may offer useful parameters with which to gauge bone disease progression and response to therapy. Data acquired using near infrared spectroscopy (NIRS) will be compared to DEXA (Dual Energy X-ray Absorptiometry) and ultrasound, both of which are commonly used for assessment of bone health.
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