This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.POISe is a technique for imaging and/or determining the optical properties of a turbid sample by measuring its surface displacement following irradiation with a short (<10 ns) laser pulse. The technique is enabled by a modified Mach-Zehnder interferometer capable of measuring surface displacements with an axial precision of 0.5 nm, and a temporal resolution of 4 ns.The absorption and reduced scattering coefficients are determined byfitting the POISe measurement to model functions that describe thetime-resolved surface deformation as a function of optical andthermophysical properties of the target.We present the capabilities of the instrument and a few preliminaryresults of the POISe system used to determine the optical properties oftwo homogeneous, turbid tissue phantoms. We show that the absorption andreduced scattering coefficients estimated by POISe are in relatively goodagreement with those derived through the more established method offrequency domain photon migration (FDPM).
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