The bactericidal/permeability increasing protein (BPI) is a potent antimicrobial agent of 456 residues. BPI resides in the lysosomal granules of polymorphonuclear neutrophils, which are mobilized by the host to kill invading microorganisms. Recently, the structure of BPI was solved to 2.4 E resolution in our laboratory. We wish to continue structural studies on this portein to further characterize the structure to higher resolution, as well as determine cocrystal structures of BPI with several physiologically relevant ligands that will help elucidate its function.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001209-20
Application #
6119497
Study Section
Project Start
1999-03-01
Project End
2000-04-14
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
20
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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