Mutations in key structural residues of the HSOD b-barrel can lead to the lethal neurodegenerative disease amyotrophic lateral sclerosis in heterozygous human patients. We want to investigate the folding properties of Greek key b-barrels and determine the structures of HSOD mutant and permutant.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001209-22
Application #
6437468
Study Section
Project Start
2001-03-01
Project End
2002-02-28
Budget Start
Budget End
Support Year
22
Fiscal Year
2001
Total Cost
$143,176
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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