Glutamine synthetase is known to be important in the metabolism of M. tuberculosis, the organism that causes tuberculosis. Tuberculosis kills more people (about 3,000,000/year) than any other preventable disease, and is increasingly resistent to antibiotics. Because of the importance of GS to its metabolism, and because of the difference of mammalian and bacterial GSs, GS is a logical target for anti-tuberculosis drugs. A high resolution structure for bacterial GS is important for rational drug design. Understanding the mechanism of inhibition of GS12 could be helpful.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001209-23
Application #
6586541
Study Section
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
$143,176
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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