EndoIV is a DNA repair enzyme. Its activity is to catalyze the cleavage of DNA at apurinic sites. Recent reports show that nitric oxide and superoxide trigger endoIV expression suggesting that endoIV is important for survival of pathogens. We would like to solve the structure of endoIV to explain the mechanism of this enzyme.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR001209-23S1
Application #
6658617
Study Section
Project Start
2002-03-01
Project End
2003-02-28
Budget Start
Budget End
Support Year
23
Fiscal Year
2002
Total Cost
$143,176
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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