This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Several projects are described that include a range of important biological problems and technical challenges. These include: (1) Proteasome activator complexes, which include complexes of 30 or more protein subunits with a mass in excess of 1 MDa; (2) Protein complexes and machines that are relevant to understanding of HIV budding, assembly, and maturation; (3) Structures of a chromatin remodeling complex. And (4) Enzymes of tetrapyrrole biosynthesis. All of these projects require access to synchrotron radiation because the crystals are small, the structures are very large, and/or the structure determination requires anomalous diffraction.
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