This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Our goal is to collect single crystal x-ray diffraction data for the determination of therapeutic protein targets in complex with inhibitors derived from our proprietary scaffold discovery platform. These co-crystal structures will be used to prioritize and guide our chemistry effort on inhibitor optimization. These therapeutic protein targets include the Pim1 proto-oncogene kinase, which is a target of aberrant somatic hyper-mutations in diffuse cell lymphoma; PDE4, which is a target for inflammatory diseases such as asthma and COPD and other targets in the kinase and phosphodiesterase families. The co-crystal structures determined from datasets collected at SSRL under the previous proposal have not only made tremendous impact on our internal drug discovery effort but have also resulted in publications that have benefited the scientific communication in general.
Showing the most recent 10 out of 604 publications