Comparative Experimental Evaluations of Dental Implants: Biomaterial

Steflik, David E.

Abstract

(Supported in part by NIH DEO R298586 to D. Steflik). This long-term comparative project uses the HVEM/IVEM to obtain 3-D structural information on the biological characteristics of dental implant systems which are representative of currently used implants. The work is based on an in vivo dog model which permits macroscopic and microscopic evaluations of how the oral tissue (bone, connective tissue and epithelium) responds to endosteal dental implants at various time periods. HVEM of thick sections has been shown by Dr. Steflik to be the method of choice for studying bone-dental implant interfaces. Steflik, D.E., R. S. Corpe, F.T. Lake, A.L. Sisk, G.R. Parr, P.J. Hanes and K. Buttle. (1997) Composite morphology of the bone and associated support-tissue interfaces to osseointegrated dental implants: TEM and HVEM analyses. Internat. J. Oral Maxillofacial Implants 12:443-453. Steflik, D.E., F.T. Lake, A.L. Sisk, G.R. Parr, P.J. Hanes and K.F. Buttle. (1997) Transmission electron microscopy of the interfacial tissues apposing osseointegrated implants. J. Dent. Res., 75:400. Steflik, D.E., T.F. lake, A.L. Sisk, G.R. Parr, P.J. Hanes and K.F. Buttle. (1997) Tissue interfaces to dental implants: Electron microscopic analyses. Fifth World Biomaterials Congress, May 29-June, 2, 1997, Toronto, Canada. Steflik, D.E., R.S. Corpe, F.T. Lake, T.R. young, A.L. Sisk, G.R. Parr, P.J. hanes and D.J. Berkery. (1997) Ultrastructural analyses of the attachment (bonding) zone between bone and implanted biomaterials. J. Biomed. Mater. Res. (in press).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Biotechnology Resource Grants (P41)
• Project #: 5P41RR001219-17
• Application #: 6280719
• Project Start: 1998-01-01
• Project End: 1998-12-31
• Budget Start: 1997-10-01
• Budget End: 1998-09-30
• Support Year: 17
• Fiscal Year: 1998

Institution

• Name: Wadsworth Center
• DUNS #: 110521739
• City: Menands
• State: NY
• Country: United States
• Zip Code: 12204

Publications

Booth, David M; Enyedi, Balázs; Geiszt, Miklós et al. (2016) Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface. Mol Cell 63:240-248

Mannella, Carmen A; Lederer, W Jonathan; Jafri, M Saleet (2013) The connection between inner membrane topology and mitochondrial function. J Mol Cell Cardiol 62:51-7

Takvorian, Peter M; Buttle, Karolyn F; Mankus, David et al. (2013) The multilayered interlaced network (MIN) in the sporoplasm of the microsporidium Anncaliia algerae is derived from Golgi. J Eukaryot Microbiol 60:166-78

Forbes, Stephen J; Martinelli, Daniel; Hsieh, Chyongere et al. (2012) Association of a protective monoclonal IgA with the O antigen of Salmonella enterica serovar Typhimurium impacts type 3 secretion and outer membrane integrity. Infect Immun 80:2454-63

Wang, Ruiwu; Zhong, Xiaowei; Meng, Xing et al. (2011) Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. J Biol Chem 286:12202-12

Marko, Michael; Leith, Ardean; Hsieh, Chyongere et al. (2011) Retrofit implementation of Zernike phase plate imaging for cryo-TEM. J Struct Biol 174:400-12

Springer, Deborah J; Ren, Ping; Raina, Ramesh et al. (2010) Extracellular fibrils of pathogenic yeast Cryptococcus gattii are important for ecological niche, murine virulence and human neutrophil interactions. PLoS One 5:e10978

Li, Chunhao; Sal, Melanie; Marko, Michael et al. (2010) Differential regulation of the multiple flagellins in spirochetes. J Bacteriol 192:2596-603

McEwen, Bruce F; Dong, Yimin (2010) Contrasting models for kinetochore microtubule attachment in mammalian cells. Cell Mol Life Sci 67:2163-72

Palladino, Michael J (2010) Modeling mitochondrial encephalomyopathy in Drosophila. Neurobiol Dis 40:40-5