Specific signalling via surface-anchored peptides or proteins suggests the development of surface coatings which act as stealth backgrounds, anchoring the trigger molecules or clusters of recognition sites such that they are accessible to cell receptors. Rather than tailoring fixed distances between recognition sites on a specific model surface, we would like the cell to rearrange the trigger molecules to their needs, as occurs regularly in nature. The goal of this project is to develop model systems in which the recognition sites are anchored in a stealth matrix yet can move laterally. ESCA and SIMS are being used to characterize the as-prepared surfaces.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001296-18
Application #
6656585
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
18
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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