This revised proposal requests 4-year support for a BRTP Biomedical Computing Resource that emphasizes quantitative biomedical imaging. Goals are to 1) develop new computing technologies important to health- related research, 2) collaborate with biomedical scientists to solve problems requiring advanced computing techniques, 3) make Resource capabilities accessible to investigators, 4) train scientists in biomedical computing, and 5) develop and field useful biomedical- computing systems, locally and nationally. Technological R&D spans theoretical developments through implementation and exportation of systems. Theoretical developments include modeling of biological phenomena and of transduction for data acquisition. The development of computing methodologies includes 1) modeling plus algorithm development for abstracting image information from measurement data, 2) the application of high-performance processors, and 3) the development of systems that can be expeditiously transported and integrated into the environments of our collaborators and the broader scientific community. Specific areas of core research include 1) algorithms for advancing positron-emission tomography by improving attenuation corrections, applying information from other sources to image estimations, and extending current methods to 3-dimensional data, 2) modeling and image-estimation methods for improving both scanning and computational optical-sectioning microscopy, and 3) new approaches to global shape modeling and image representation to accommodate multiple levels of variability in multi-dimensional biomedical images. Technological development includes 1) exploitation of both SIMD and MIMD parallel-processing methods for achieving useful performance of computationally challenging algorithms, and 2) high-speed communication systems for distributing Resource capabilities to dispersed sites for both technological and biomedical research. An integrated environment for quantitative-imaging research is maintained. Collaborative research includes 9 intramural (Washington University) and 9 extramural projects in: functional brain mapping, cognitive neuroscience, myocardial and tumor imaging, statistical methods in image analysis, cerebral blood flow via MRI, multicellular morphogenesis, embryonic actin-binding proteins, postsynaptic-receptor plasticity, high- resolution fluorescence microscopy, anti-HIV oligonucleotides, pattern- theoretic methods, deformable topologic templates, radiation-treatment planning, ocular-fundus imaging, ATM-based networking, genetic-linkage analysis, cellular biochemistry in cardiac ischemia, scatter corrections for PET, DNA mapping, and electron-microscopic autoradiograph analysis. Four Resource technologies provide user service for 10 intramural and 5 extramural research projects.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR001380-12A1
Application #
3103882
Study Section
Special Emphasis Panel (ZRG7-SSS-9 (01))
Project Start
1981-12-01
Project End
1996-05-31
Budget Start
1993-07-01
Budget End
1994-05-31
Support Year
12
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Preza, C (2000) Rotational-diversity phase estimation from differential-interference-contrast microscopy images. J Opt Soc Am A Opt Image Sci Vis 17:415-24
Preza, C; Snyder, D L; Conchello, J A (1999) Theoretical development and experimental evaluation of imaging models for differential-interference-contrast microscopy. J Opt Soc Am A Opt Image Sci Vis 16:2185-99
Hong, B; Ichida, A; Wang, Y et al. (1999) Identification of a calmodulin-regulated Ca2+-ATPase in the endoplasmic reticulum. Plant Physiol 119:1165-76
Huang, W; Fuhrmann, D R; Politte, D G et al. (1998) Filter matrix estimation in automated DNA sequencing. IEEE Trans Biomed Eng 45:422-8
Schuster, D P; Markham, J; Welch, M J (1998) Positron emission tomography measurements of pulmonary vascular permeability with Ga-68 transferrin or C-11 methylalbumin. Crit Care Med 26:518-25
Cubitt, A B; Reddy, I; Lee, S et al. (1998) Coexpression of a constitutively active plasma membrane calcium pump with GFP identifies roles for intracellular calcium in controlling cell sorting during morphogenesis in Dictyostelium. Dev Biol 196:77-94
Reuzeau, C; Doolittle, K W; McNally, J G et al. (1997) Covisualization in living onion cells of putative integrin, putative spectrin, actin, putative intermediate filaments, and other proteins at the cell membrane and in an endomembrane sheath. Protoplasma 199:173-97
Huang, W; Yin, Z; Fuhrmann, D R et al. (1997) A method to determine the filter matrix in four-dye fluorescence-based DNA sequencing. Electrophoresis 18:23-5
Christensen, G E; Joshi, S C; Miller, M I (1997) Volumetric transformation of brain anatomy. IEEE Trans Med Imaging 16:864-77
Matthews, J W; Rosenberger, F U; Bosch, W R et al. (1996) Real-time 3D dose calculation and display: a tool for plan optimization. Int J Radiat Oncol Biol Phys 36:159-65

Showing the most recent 10 out of 41 publications