This program continues our present interdisciplinary approach to effect solutions to new molecular identification and quantification problems in the chemical, biochemical, biomedical and clinical research areas of direct relevance to human health. The program will make available to investigators from a wide spectrum of biomedical research disciplines state-of-the-art techniques in high performance computerized double focusing mass spectrometry and the expertise necessary to apply successfully such unique instrumentation to their research problems. We will continue to foster developments in mass spectrometry and computer technology which will facilitate solutions for: 1) structure determinations of polar, polyfunctional, labile biological substances in the microgram sample range and below; 2) studies of the qualitative and quantitative composition of complex mixtures isolated from biological sources with emphasis on: field desorption, fast atom/ion bombardment, collision cell work, linked scanning, extended mass range, higher mass resolutions, glass capillary gas chromatography/high resolution mass spectrometry, and elementatl composition chromatgraphy. Specific areas of clinical importance include: Steroid endocrinology and hypertension, drug metabolism and conjugation, the molecular basis of toxicity, mutagenicity and carcinogenesis, and gentic diseases. Studies in organic, natural products and biochemistry will also continue.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001614-04
Application #
3103912
Study Section
(SSS)
Project Start
1982-03-01
Project End
1986-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Pharmacy
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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