Abstract

Glutamatergic synaptic transmission in the brain is mediated primarily by AMPA and NMDA receptor-channel subtypes. Both of these subtypes of receptor-channels also are subject to activity-dependent changes in synaptic strength, known as long-term potentiation (LTP) and long-term depression (LTD), which must reflect underlying changes in receptor-channel function. The precise neurobiological mechanisms responsible for phenomena such as LTP and LTD are as yet unknown, however, and many putative mechanisms involve properties of receptor-channels that are difficult or impossible to measure experimentally. We are collaborating with Dr. Michel Baudry (and also Dr. Gilbert Chauvet of the University of Angers, France; see Project 2) to develop a detailed synaptic model of the glutamatergic synapse that includes molecular mechanisms of presynaptic release of neurotransmitter and postsynaptic mechanisms of the kinetics of both AMPA and NMDA receptors. Also included is the geometry of the synaptic cleft, and thus, the spatial relations between the presynaptic release sites and the postsynaptic receptors. This model is being used to help interpret experimental data generated in Dr. Baudry's lab to resolve issues related to potential mechanisms underlying LTP and LTD. Dr. Baudry's work on this project is supported by the NIMH MH 52194.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001861-18
Application #
6611250
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
18
Fiscal Year
2002
Total Cost
$155,764
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Song, Dong; Wang, Haonan; Tu, Catherine Y et al. (2013) Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions. J Comput Neurosci 35:335-57
Hoppenbrouwers, Toke; Oliveira, Flavia; Sandarupa, Stanislaus et al. (2012) The development of the circadian heart rate rhythm (CHR) in Asian infants. Early Hum Dev 88:555-61
Wang, Xiaoning; Schumitzky, Alan; D'Argenio, David Z (2007) Nonlinear Random Effects Mixture Models: Maximum Likelihood Estimation via the EM Algorithm. Comput Stat Data Anal 51:6614-6623
Gholmieh, Ghassan; Courellis, Spiros; Marmarelis, Vasilis et al. (2007) Nonlinear dynamic model of CA1 short-term plasticity using random impulse train stimulation. Ann Biomed Eng 35:847-57
Gholmieh, Ghassan; Courellis, Spiros; Dimoka, Angelika et al. (2004) An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings. J Neurosci Methods 136:111-21
Ashjian, Peter; Elbarbary, Amir; Zuk, Patricia et al. (2004) Noninvasive in situ evaluation of osteogenic differentiation by time-resolved laser-induced fluorescence spectroscopy. Tissue Eng 10:411-20
Jo, Javier A; Blasi, Anna; Valladares, Edwin et al. (2003) Model-based assessment of autonomic control in obstructive sleep apnea syndrome during sleep. Am J Respir Crit Care Med 167:128-36
Belozeroff, Vasily; Berry, Richard B; Khoo, Michael C K (2003) Model-based assessment of autonomic control in obstructive sleep apnea syndrome. Sleep 26:65-73
Bading, James R; Yoo, Paul B; Fissekis, John D et al. (2003) Kinetic modeling of 5-fluorouracil anabolism in colorectal adenocarcinoma: a positron emission tomography study in rats. Cancer Res 63:3667-74
Xu, Lu; Eiseman, Julie L; Egorin, Merrill J et al. (2003) Physiologically-based pharmacokinetics and molecular pharmacodynamics of 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite in tumor-bearing mice. J Pharmacokinet Pharmacodyn 30:185-219

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