Abstract

OUR STUDY OF THE ROLE OF THE PRIMARY INFECTION IN THE SPREAD OF THE HIV APPEARED IN THE J. AIDS IN NOVEMBER, 1994. THAT PAPER HAS HAD A MAJOR IMPACT ON THE FIELD. NOW, MOST WORKERS IN THE FIELD ARE CONVINCED THAT THE PRIMARY INFECTION IS THE MOST INFECTIOUS PERIOD OF THE DISEASE. OUR SUBSEQUENT WORK HAS SHOWN THAT EVEN IN THE ENDEMIC STATE, A MAJOR PORTION OF THE TRANSMISSIONS COME FROM INDIVIDUALS WHO ARE IN THE PRIMARY INFECTION. THAT HAS LED US TO INVESTIGATE THE POTENTIAL OF VACCINES FOR CONTROL OF THE SPREAD OF THE HIV. OUR CURRENT RESULTS STRONGLY SUGGEST THAT A VACCINE THAT DOES NOT PREVENT INFECTION (HIGHLY LIKELY WITH THE HIV) BUT THAT CAN MARKEDLY DECREASE THE VIREMIA OF THE PRIMARY INFECTION COULD DECREASE SPREAD SUFFICIENTLY TO STOP THE EPIDEMIC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR002176-10
Application #
5223832
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Vicini, P; Caumo, A; Cobelli, C (1999) Glucose effectiveness and insulin sensitivity from the minimal models: consequences of undermodeling assessed by Monte Carlo simulation. IEEE Trans Biomed Eng 46:130-7
Burnett, J R; Wilcox, L J; Telford, D E et al. (1999) The magnitude of decrease in hepatic very low density lipoprotein apolipoprotein B secretion is determined by the extent of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition in miniature pigs. Endocrinology 140:5293-302
Vicini, P; Cobelli, C (1999) A priori identifiability of distributed models of blood-tissue exchange. Ann Biomed Eng 27:200-7
Cobelli, C; Caumo, A; Omenetto, M (1999) Minimal model SG overestimation and SI underestimation: improved accuracy by a Bayesian two-compartment model. Am J Physiol 277:E481-8
Vicini, P; Barrett, P H; Cobelli, C et al. (1998) Approaches to population kinetic analysis with application to metabolic studies. Adv Exp Med Biol 445:103-13
Bertoldo, A; Vicini, P; Sambuceti, G et al. (1998) Evaluation of compartmental and spectral analysis models of [18F]FDG kinetics for heart and brain studies with PET. IEEE Trans Biomed Eng 45:1429-48
Barrett, P H; Bell, B M; Cobelli, C et al. (1998) SAAM II: Simulation, Analysis, and Modeling Software for tracer and pharmacokinetic studies. Metabolism 47:484-92

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