This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We intend to study relaxation processes in small monomeric enzymes as a function of temperature to test whether catalytic activity and molecular motions can be correlated. Initially HSQC data will be collected to verify the assignability of spectra, followed by relaxation studies.
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