This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We are working on determining the structure of a complex between the TAF110 domain of AML1-ETO and a peptide from the E box protein HEB. This interaction has been proposed to be important for the leukemogenesis mediated by AML1-ETO so structural information will provide a platform to test the importance of this interaction for AML1-ETO mediated leukemogenesis.
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