This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We plan to investigate structural changes from native states to amyloidogenic states with dynamics experiments. A very low peptide concnetration (20uM) is required to aviod aggregations and thus high filed faciltities (800 or 900) is highly desirable, which will improve the resolution for the unfolded states.
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