This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Physis (epiphyseal plate or growth plate) is the hyaline cartilage plate in the distal ends of long bones facilitating lengthwise growth in children and adolescents. The fracture, trauma or radiation involving Physis could hamper cellular growth and result in premature arrest of bone development. The affected bone could be shorter or crooked and if the injury diagnosed early can be intervened to change the course of development. Fifteen percent of pediatric growth fractures in age groups 10 -16 involve growth plate and fifty percent of them involve distal Radii. Typically Physis fracture shows as radiolucent gap on conventional radiography but soft tissue changes in the plate can be better visualized by Ultrasound and MRI. In previous studies, proteoglycan (PG) rich articular cartilage and intervertebral discs has been shown to be sensitive to T1 MRI technique. In this study, we would like to investigate the quantitative change in PG content to diagnose growth plate fracture in distal Radii and to determine the extent of the impact that the fracture has on the normal growth of the bone.
Showing the most recent 10 out of 414 publications
