This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.
Our aim i s to develop morphological models correlating characteristic spectral signatures (e.g., inverse power law scattering coefficients) to specific sub-cellular or tissue components (e.g., nuclear chromatin, mitochondria, superficial keratin layer, collagen matrix). Mie theory and Rayleigh-Gans calculations are carried out for optimizing size-selectivity of the ALSS technique. We also examine and develop new fractal tissue models, such as Born/von Karman model, for human epithelia, and verify our model predictions via laboratory cell monolayer, cell raft and/or ex vivo tissue studies.
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