This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Bronchial asthma afflicts more than 10% of the U.S. population, and the incidence and prevalence are on the rise. A critical feature of the disease is structural changes in the wall of the airways, which become more prominent as the disease progresses, and are correlated with disease severity and symptoms. It is not clear whether these changes are a normal response to an abnormal injury, or whether the response itself is abnormal. In addition, there is inadequate information describing the mechanisms of airway remodeling to determine whether the structural changes are reversible. The major changes in the airway wall include mucus cell hyperplasia, subepithelial fibrosis, angiogenesis, and smooth muscle cell hyperplasia. We are developing in vitro models to address all of these features, with a central hypothesis that the bronchial epithelial cell orchestrates and modulates each of these processes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR003155-26
Application #
8365761
Study Section
Special Emphasis Panel (ZRG1-BCMB-K (40))
Project Start
2011-08-20
Project End
2012-06-30
Budget Start
2011-08-20
Budget End
2012-06-30
Support Year
26
Fiscal Year
2011
Total Cost
$2,033
Indirect Cost
Name
University of California Irvine
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
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