This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The S.A.G.E. (Statistical Analysis for Genetic Epidemiology) computer program package provides researchers with the tools necessary for various types of statistical genetic analysis of human family data. Prior to the funding of this resource, few such computer programs were available, and those in existence were usually poorly documented and not easily transportable from one type of computer to another. This subproject has addressed these problems by developing computer programs for genetic analysis that are well documented and portable between different computers and operating systems. S.A.G.E. version 3.0 was released in March, 1997. This version was written in ANSI standard C. A fully functional production release for both Windows and Unix was made available in 1999 in version 3.1. A beta release of 4.0 with enhanced capabilities was made available in 2001. Beginning in May, 2002 there was a 4.x new release every few months, each time with further enhancements. The most recent release, 5.2, released in June, 2006, incorporated a new data querying feature that allows the user to easily stratifiy the data set using simple SQL commands. The Graphical User Interface (GUI)has built-in wizards for constructing pedigree files, parameter files and genome description files, with a series of point and click menus, resulting in a very user friendly program. In the past year a completely new program, DECIPHER, was released that estimates haplotype frequencies from family and population data. In addition, major enhancements were made to the programs SEGREG, SIBPAL, and FREQ.
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