This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Numerous studies suggest the evidence of genes that predispose to development of autoimmunity that may progress to any of a number of diseases with overlapping features such as autoantibody production. This study is designed to evaluated various autoimmunity traits for use as intermediate phenotypes to map genes involved in systemic lupus erythematosus and related autoimmune diseases. A genome scan of several of these trais was recently published and results indicate that, while autoantibody production is a complex trait, there is indeed evidence to support genes specific to cerain autoantibodys and use of these intermediate phenotypes hold promise of providing insight into multiple autoimmune traits.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR003655-21
Application #
7420640
Study Section
Special Emphasis Panel (ZRG1-GGG-J (40))
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
21
Fiscal Year
2006
Total Cost
$7,388
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Elston, Robert C; Satagopan, Jaya; Sun, Shuying (2017) Statistical Genetic Terminology. Methods Mol Biol 1666:1-9
Thota, Prashanthi N; Zackria, Shamiq; Sanaka, Madhusudhan R et al. (2017) Racial Disparity in the Sex Distribution, the Prevalence, and the Incidence of Dysplasia in Barrett's Esophagus. J Clin Gastroenterol 51:402-406
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Castiblanco, John; Sarmiento-Monroy, Juan Camilo; Mantilla, Ruben Dario et al. (2015) Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome. J Immunol Res 2015:572353
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