Abstract

Stroke drug trials are often inconclusive. Opposing results are commonly reported due to the multitude of experimental animal models. Most important in this discussion is the influence of blood pressure, temperature, and species on the outcome of stroke drug trials. However, even with strict control of physiological variables, stroke volumes vary experimentally. Often large numbers of experimental animals are required for a conclusive outcome study. We investigated the possibility of using the change in stroke volume observed acutely (1- 8 hrs) on diffusion-weighted MRIs as a basis for stroke drug trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR005959-07
Application #
5225121
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

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Huang, Lingling; Walter, Vonn; Hayes, D Neil et al. (2014) Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. Clin Cancer Res 20:1566-75
Huang, Jing; Guo, Jian; Beigi, Farideh et al. (2014) HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. J Mol Cell Cardiol 66:157-64
Yuan, Ying; Gilmore, John H; Geng, Xiujuan et al. (2014) FMEM: functional mixed effects modeling for the analysis of longitudinal white matter Tract data. Neuroimage 84:753-64
He, Mu; Kaushik, S Sivaram; Robertson, Scott H et al. (2014) Extending semiautomatic ventilation defect analysis for hyperpolarized (129)Xe ventilation MRI. Acad Radiol 21:1530-41
Davis, Ryan M; Viglianti, Benjamin L; Yarmolenko, Pavel et al. (2013) A method to convert MRI images of temperature change into images of absolute temperature in solid tumours. Int J Hyperthermia 29:569-81

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