Mice with segmental trisomy 16 (Ts65Dn mice) are at gene dosage imbalance for many of the same genes triplicated in human beings with Down Syndrome (DS), the leading genetic cause of mental retardation in human beings. Marked changes in brain volume and development are notable in DS. We have recently shown that Ts65Dn mice have a marked deficit in learning and memory tasks. We wish to compare the structure of affected mouse brains to controls, initially in adults and subsequently during development. Results will be compared to ongoing MRI studies of DS individuals at Johns Hopkins.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR005959-10
Application #
6220745
Study Section
Project Start
1999-09-15
Project End
2000-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
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