This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing proprietary SPIO (superparamagnetic iron oxide) contrast agents and are currently evaluating them in an rat model of MS (acute experimental autoimmune encephalomyelitis, EAE). Because at our facility we are presently limited to scanning using a 1.5 T clinical scanner, we interested in exploring whether the higher field and resolution that your facility is capable of providing could significantly aid in our evalution of these new agents. We propose a pilot study to quantify the contrast to noise that can be observed in the brain/upper spinal cord lesions that are present in the EAE model. This could be done either on tissue samples (or carcasses) that we prepare and then send to you, or it could be done on live rats at your fac
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