This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The issue of papillary necrosis is often discussed in kidney transplantation and in renal failure consecutive to the use of nephrotoxic drugs. Various imaging techniques have been proposed, but only an invasive methodology with renal biopsy can readily assess this condition a procedure that may have to be performed repeatedly to address the problem.
The aims of this study are to: 1) use MRM to identify the region of tubular necrosis in a specimen, and 2) follow the functional changes induced by papillary necrosis using dynamic contrast enhancement.
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