This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The goal of this research is to understand how innate immunity regulates host susceptibility to chronic lung disease through studies focused on post-transplant bronchiolitis obliterans syndrome (BOS). Although lung transplantation represents a life-saving therapy for many patients with advanced lung diseases, some patients develop frequent or severe episodes of acute rejection, characterized by perivascular lymphocytic infiltrate and lymphocytic bronchiolitis. These episodes substantially increase the risk for the development of BOS, a condition of chronic allograft rejection leading to progressive airflow obstruction and bronchiolar fibrosis. As a result of BOS, median survival after lung transplant is much lower than observed after transplantation of other solid organs. We will test this hypothesis in both patients undergoing lung transplant and in a murine BMT model of lung transplant rejection.
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