Antisense, ribozymes, and RNA-decays are oligonucleotides that can be used as new and powerful tools to specifically inhibit the expression of a chosen protein. Our strategy is to develop antisense, ribozyme, and decoy expression vectors against a number of target proteins(such as oncogenes and receptors) such that they can be used as new anti-cancer gene therapy. Liposomes are used as a means to deliver these expression vectors into the target cells, upon which they are expressed.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR006009-09S1
Application #
6295172
Study Section
Project Start
1998-09-30
Project End
1999-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Mellon Pitts Corporation (Mpc Corp)
Department
Type
DUNS #
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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