This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We study how small molecules like alcohols and sugars interact with biomembranes and alter their structure and phase behavior using molecular dynamic simulations. The biomembranes considered are cellular bilayers composed of phospholipids. Previous simulations indicate that small molecules can significantly affect the structural properties of bilayers. Molecular simulations are an ideal method for this study because dynamical properties of the lipid bilayer can be calculated unambiguously to confirm and extend experimental results. This proposal will be divided into a separate section for the simulations that include alcohols (mainly ethanol) and sugars (mainly trehalose).
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