This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Keywords:Volume data analysis, visualization and distribution collaborationAbstract:Cells, grown in a 96 well plate, are imaged using multiple modalities toidentify over 108 individual physiological cellular measurements orfeatures, including the nuclear density, cell perimeter,post-translational modifications, specific assays to calculate thepercentage of cells in S-phase and mitosis [Gasparri, et al. 2004. JBiomol Screen 9:232-243], cytoplasm-nuclear translocation,characterization of cellular toxicity, and receptor internalization. Thegoal of this project is to develop approaches to identify patterns offeatures (individual physiological cellular measurements) between cell types.
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