This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Some vital cell functions, such as growth and differentiation, are affected by the physical distortion of cells. The mechanical properties of cell membranes play an important role in physical response of cells to mechanical forces. Since more and more kinds of nano-materials are used in industries and nano-particles can easily enter into human bodies via various ways, the size effect of nano-particles on mechanical properties of cell membrane needs to be studied to evaluate the health risks of manufactured nano-products. It is proposed in this project that Molecular Dynamics (MD) simulations be performed to investigate the interaction between carbon nanotubes of various sizes and a lipid bilayer, because the simulation parameters can be controlled and examined more precisely in computer simulations than experiments. The proposed research tasks are to first develop an MD model including a single-walled carbon nanotube of specific size and a patch of lipid bilayer, and then conduct a series of MD simulations to investigate the change of mechanical properties of the bilayer as a result of the introduction of the carbon nanotubes of various sizes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR006009-18
Application #
7723297
Study Section
Special Emphasis Panel (ZRG1-BCMB-Q (40))
Project Start
2008-08-01
Project End
2009-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
18
Fiscal Year
2008
Total Cost
$473
Indirect Cost
Name
Carnegie-Mellon University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
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