The National Resource for Biomedical Supercomputing (NRBSC) will perform and enable leading edge biomedical research, training, and dissemination based on high performance computing and communications. To achieve this goal we will: -Play a leading role in Core and Collaborative research focused on: -spatially realistic cell modeling based on Monte Carlo algorithms -molecular modeling based on polarizable force fields and hybrid quantum mechanical/molecular mechanical algorithms -shared visualization, manipulation, and analysis of massive volumetric datasets -Promote multidisciplinary biological and computational expertise in the nation's biomedical research community through: -a proven outstanding training program focused on our primary research areas -state-of-the-art web gateways to the NRBSC and primary software packages under development at the NRBSC (MCell, DReAMM, PSC-VB, DYNAMO) -a state-of-the-art open software licensing and distribution mechanism tailored to the needs of complex scientific codes and developers working in an academic setting -innovative, integrated educational tools designed for broad audiences and based on state-of-the-art web development tools The NRBSC is hosted by the Pittsburgh Supercomputing Center, a leading national resource for academic supercomputing. The NRBSC thus is uniquely qualified to advance the nation's progress in biomedical research through high performance computing.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR006009-19S1
Application #
7928327
Study Section
Special Emphasis Panel (ZRG1-BCMB-Q (40))
Program Officer
Brazhnik, Olga
Project Start
1997-09-01
Project End
2010-07-31
Budget Start
2009-09-23
Budget End
2010-07-31
Support Year
19
Fiscal Year
2009
Total Cost
$401,363
Indirect Cost
Name
Carnegie-Mellon University
Department
Biostatistics & Other Math Sci
Type
Schools of Arts and Sciences
DUNS #
052184116
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Simakov, Nikolay A; Kurnikova, Maria G (2018) Membrane Position Dependency of the pKa and Conductivity of the Protein Ion Channel. J Membr Biol 251:393-404
Yonkunas, Michael; Buddhadev, Maiti; Flores Canales, Jose C et al. (2017) Configurational Preference of the Glutamate Receptor Ligand Binding Domain Dimers. Biophys J 112:2291-2300
Hwang, Wonmuk; Lang, Matthew J; Karplus, Martin (2017) Kinesin motility is driven by subdomain dynamics. Elife 6:
Earley, Lauriel F; Powers, John M; Adachi, Kei et al. (2017) Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11. J Virol 91:
Subramanian, Sandeep; Chaparala, Srilakshmi; Avali, Viji et al. (2016) A pilot study on the prevalence of DNA palindromes in breast cancer genomes. BMC Med Genomics 9:73
Ramakrishnan, N; Tourdot, Richard W; Radhakrishnan, Ravi (2016) Thermodynamic free energy methods to investigate shape transitions in bilayer membranes. Int J Adv Eng Sci Appl Math 8:88-100
Zhang, Yimeng; Li, Xiong; Samonds, Jason M et al. (2016) Relating functional connectivity in V1 neural circuits and 3D natural scenes using Boltzmann machines. Vision Res 120:121-31
Lee, Wei-Chung Allen; Bonin, Vincent; Reed, Michael et al. (2016) Anatomy and function of an excitatory network in the visual cortex. Nature 532:370-4
Murty, Vishnu P; Calabro, Finnegan; Luna, Beatriz (2016) The role of experience in adolescent cognitive development: Integration of executive, memory, and mesolimbic systems. Neurosci Biobehav Rev 70:46-58
Jurkowitz, Marianne S; Patel, Aalapi; Wu, Lai-Chu et al. (2015) The YhhN protein of Legionella pneumophila is a Lysoplasmalogenase. Biochim Biophys Acta 1848:742-51

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