This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The -CFT class of bacterial toxins are important bacterial toxins; they are the causative agents of tissue destruction in a variety of serious bacterial diseases and pose important and lucrative drug targets. The members of the -CFT class of bacterial toxins have all proven to be poorly diffracting crystals that are both small and fragile. Each different structure has had to be solved by either MAD or MIR as the arrangement of domains in three dimensions are not similar enough to allow molecular replacement. Therefore the use of synchrotron radiation for this program is vital.
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