This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this study is to test the hypothesis that myolaminate morphology becomes more homogenous as the strain pattern becomes more homogenous. Normal rat hearts have much heterogeneity (in the transmural dimension) in both strain and myolaminate morphology. The dilated rat heart has a more homogeneous strain pattern, yet the myolaminate morphology is presently unknown. To obtain our goal, it is necessary to measure microstructural parameters at convenient, discrete locations and use 3D spatial interpolation to reconstruct the myolaminate morphology of the rat septum in normal and dilated hearts. Continuity will be used for our anatomical fitting. A database of rodent anatomy and microstructural data will be crucial for my investigations of cardiac growth and remodeling in rodent models of cardiac hypertrophy. I plan on contributing data on the rat septum from my AHA grant and using available data and Continuity to model and better interpret how myocardium grows and remodels.
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