This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Biologists study phenomena at multiple levels of granularity, ranging from genome-wide protein-protein and protein-DNA interactions, to gene function assignment by homology to 3D structures and molecular interactions to force-field and quantum chemical analysis of molecular conformations and interactions, up to the levels of the cellular models, multicellular phenomena in tissues and organs. For different levels of granularity, scientists use different techniques to acquire, model, represent and analyze information. The central focus of this core is to develop and deploy an integrative environment (in the form of an application, as well as an API, that will be served through NBCR) which enables a scientist to search for and correlate biological information from multiple scales and from multiple data sources using novel data modeling and integration techniques.
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