This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There are both formal and informal parts to the training done by BioCAT. Formal activities in the last year involved lectures on fiber diffraction and solution scattering in the ACA crystallography summer school and participation by Dr. Barrea and Dr. Weng in hands-on workshops as part of the APS XAFS summer school. All new users need to be trained to use our beamline and in many cases, especially for SAXS, users are often new to the technique itself. In the last year 47 new users were trained by BioCAT staff and of those, we can identify 5 user groups that were new to the technique of SAXS. A central part of our training activities is the SAXS and Fiber Diffraction Workshops where a number of groups, usually a mixture of experienced and inexperienced users share a beamtime allocation. There is at least one SAXS and usually one fiber diffraction workshop/run. Microprobe experiments are less amenable to this format so training is one on one between staff and experimental group. We intend, however, to have training sessions in micro-emission spectroscopy as part of the next APS XAFS summer school. Finally, students and post-docs in Prof Irving's and Orgel's laboratories, because of the ready access to the facility, have a unique opportunity to be trained as future leaders of their fields. One recent graduate, Dr. G. Farman, is still very active in muscle fiber diffraction on the basis of his training and interactions with collaborators in the Irving lab.
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| Yazdi, Aliakbar Khalili; Vezina, Grant C; Shilton, Brian H (2017) An alternate mode of oligomerization for E. coli SecA. Sci Rep 7:11747 |
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| Zhou, Hao; Li, Shangyang; Badger, John et al. (2015) Modulation of HIV protease flexibility by the T80N mutation. Proteins 83:1929-39 |
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