This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. INTRODUCTION There is a correlation between reading performance and white matter structure in a left temporo-parietal region measured with diffusion tensor imaging (DTI). Here we analyze the major neural pathways coursing through this region. MATERIALS AND METHODS We used whole-brain DTI to measure the fractional anisotropy (FA) in normal and poor readers aged 7 to 13 (n=14). Groups were matched in age, SES and non-verbal IQ. We identified a region of interest (ROI) of about 200 mm3 in which the group FA values differed significantly (Deutsch in press; Klingberg 2000). We then used fiber tracing (Mori 2002) to identify the major pathways passing through this ROI. REFERENCES 1. Deutsch et al. (in press). Correlations between white matter microstructure and reading performance in children. Cortex. 2. Klingberg et al. (2000). Microstructure of temporal-parietal white matter as a basis for reading ability: Evidence from diffusion tensor magnetic resonance imaging. Neuron, 25:493-500. 3. Mori et. al. (2002). Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. MRM, 47:215-223
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