This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Introduction: Turner syndrome (TS) provides a model for elucidating critical linkages among X chromosome gene function, brain development, and cognition.
Specific Aims : To determine the neurobiologic and genetic correlates of visual-spatial skills, emotion processing and executive function impairments in girls with TS compared to controls.Methods: Cognitive-behavioral and neuroimaging assessments (including volumetric MRI, functional MRI, DTI and 1H MRS) are administered to 100 subjects with TS and 50 age matched female controls. Subjects are re-assessed at 12-18 months. Local subjects additionally participate in cognitive intervention programs designed to improve visual-spatial planning or math skills. Subjects enrolled in the intervention programs are assessed before and after the intervention.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009784-14
Application #
7722899
Study Section
Special Emphasis Panel (ZRG1-SBIB-F (40))
Project Start
2008-06-01
Project End
2009-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
14
Fiscal Year
2008
Total Cost
$2,802
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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