This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Background: The effect of life stress on depression has been found to be moderated by a common polymorphism in the serotonin transporter gene (5-HTTLPR). Being a carrier of one or two copies of the short allele of this gene is associated with greater vulnerability to depression. One mediator of this relation may be the processing of emotional information.Objective: To examine neural correlates of the processing of emotional stimuli in children who are carriers of the short or the long allele to gain a better understanding of the mechanisms underlying the association of the risk allele and emotional disorders.Hypothesis: High-risk children will exhibit greater amygdala activation in response to processing emotion stimuli.Methods: Participants completed a dot-probe task while being scanned. Data was acquired on a 3T GE scanner using a spiral in/spiral out acquisition sequence (Glover, 2001). Resulting data was processed using AFNI and included manual realignment, normalization and smoothing.
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