This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Guided by the Resource Directors and staff, the following students participated in MS Resource research under the Boston University Undergraduate Research Opportunities Program in the 2004-2005 academic year. The Boston University Chemistry Dept. students all made presentations on their work at the annual Undergraduate Research Symposium. Mr. Andrew Dykstra completed work for his double major in chemistry and philosophy at Boston University and graduated in May 2004. He has worked at the Resource throughoput his undergraduate years. During this year, under the direct supervision of Dr. Th berge, he determined amino acid sequences and post-translational modifications of overexpressed immunoglobulin light chains that are associated with Primary Amyloid disease. Whenever his class schedule permitted, he also attended the weekly meeting of clinical and basic science investigators associated with the BUSM Amyloid Program. After a year of travel and specialized study, he plans tol attend graduate school to obtain a PhD in chemistry/biochemistry Ms. Marina Belyayev is also a chemistry major and joined this Resource in spring 2004. She is using electron capture dissociation FTMS spectra to differentiate between alpha-aspartic acid and beta-aspartic acid. The isomerization of alpha-aspartic acid is an aging phenomenon and may be related to protein-folding disorders. Ms. Belyayev will graduate in 2006 and expects to attend medical school. Ms. Kristin Hargett received her BS in Chemistry from Boston University in May 2004 and continued to work during the summer following graduation. She performed in-gel digestions and analysis of MALDI-TOF MS data related to the collaborative project of G. Taccioli on DNA- repair-deficient mice, under the direction of Prof. Costello and Dr. Eric Berg. She entered the PhD program in Biochemistry at Georgetown University in fall 2004. Ms. Landon is a Computer Science student at Boston University. She worked under the direction of Prof. Costello and Dr. Mark McComb, helping to set up the dedicated database for the search of hemoglobin sequence variants and post-translational modifications, a collaboration with D. Chui.
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