The objective of the project is to develop a high frequency (50 MHz), high resolution (100 fm) 2mm by 2mm linear phased array for intravascular, endoluminal, ophthalmological and dermatological imaging. Present research and commercial systems all use single element mechanical scanning which can only produce focused image over a limited depth at very low frame rate. Thus, they are susceptible to motion artifacts. A solution would be the development of linear sequenced or phased arrays. Linear phased arrays allow not only beam steering but also dynamic focusing. The problem with phased arrays however is that they are more difficult to design and fabricate due to their smaller aperture. The problems that have to be overcome in the development of very high frequency linear phased arrays are more severe than linear arrays. The element size is even smaller and the electrical impedance larger because many more elements have to be squeezed into a very small aperture. Moreover, acoustic isolation between elements becomes more difficult to achieve. To solve these problems, a sparse array approach was proposed. A novel element reduction strategy, in that a separate transmit and receive array is designed using different element spacing for each array, will be used so that the spacings between the elements are increased without degrading the beam pattern. An increase in spacing is extremely crucial in VHF linear phased array since to avoid grating lobes, the pitch has to be less than /2 which is less than 16 fm at 50 MHz and is difficult to achieve with the current dicing technology. Using the sparse array approach, an initial design indicates that the pitch can be increased to 45 fm. Selecting an element width of 20 fm, the aspect ratio and directivity requirements can be met with a kerf (spacing between elements) width of 20 fm which is still manageable with the dicing saw (K & S 782) that the Resource has. FEA of the design will be performed and fabricated arrays will be tested at Cleveland Clinic. ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR011795-04
Application #
6348243
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2000
Total Cost
$3,079
Indirect Cost
Name
Pennsylvania State University
Department
Type
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802
Reddy, Anilkumar K; Hartley, Craig J; Pham, Thuy T et al. (2014) Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci 69:152-9
Gurha, Priyatansh; Wang, Tiannan; Larimore, Ashley H et al. (2013) microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One 8:e75882
Crossland, Randy F; Durgan, David J; Lloyd, Eric E et al. (2013) A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol 305:R334-42
Nagamani, Sandesh C S; Campeau, Philippe M; Shchelochkov, Oleg A et al. (2012) Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet 90:836-46
Lee, Hyeong Jae; Zhang, Shujun (2012) Design of low-loss 1-3 piezoelectric composites for high-power transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control 59:1969-75
Lloyd, Eric E; Crossland, Randy F; Phillips, Sharon C et al. (2011) Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension 58:672-8
Hartley, Craig J; Reddy, Anilkumar K; Madala, Sridhar et al. (2011) Doppler velocity measurements from large and small arteries of mice. Am J Physiol Heart Circ Physiol 301:H269-78
Chintalgattu, Vishnu; Ai, Di; Langley, Robert R et al. (2010) Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 120:472-84
Song, Liang; Maslov, Konstantin; Shung, K Kirk et al. (2010) Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo. J Biomed Opt 15:021303
Zhang, Shujun; Sherlock, Nevin P; Meyer, Richard J et al. (2009) Crystallographic dependence of loss in domain engineered relaxor-PT single crystals. Appl Phys Lett 94:162906

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