For clinical applications in dermatology, ophthalmology and intravascular imaging, high performance single element transducer and linear arrays have to be developed. Since the piezoelectric elements used in these devices are small, they cannot be fabricated with conventional piezoelectric materials and methods. In this project, single element transducers and linear arrays in the frequency range from 30 to 80 MHz will be developed and tested using an ultrasonic backscatter microscope and a flexible beam forming system which are being developed in parallel with this project. Single element transducers ranging from 20 to 90 MHz have made using modified PT, fine grain PZT, 1-3 fiber composite and PZN-PT and performance assessed. A 48 element linear array at 30 MHz using fine grain PZT is being developed. Initial results show a bandwidth of better than 45% and a cross-talk between adjacent elements of less than -28 dB. Element to element uniformity is better than 20%. These devices will be used to image excised animal tissues and patients with the assistance from the clinicians once the UBM system and the beam former are completely developed and compared to the images obtained by conventional devices. ?
| Reddy, Anilkumar K; Hartley, Craig J; Pham, Thuy T et al. (2014) Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci 69:152-9 |
| Gurha, Priyatansh; Wang, Tiannan; Larimore, Ashley H et al. (2013) microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One 8:e75882 |
| Crossland, Randy F; Durgan, David J; Lloyd, Eric E et al. (2013) A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol 305:R334-42 |
| Nagamani, Sandesh C S; Campeau, Philippe M; Shchelochkov, Oleg A et al. (2012) Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet 90:836-46 |
| Lee, Hyeong Jae; Zhang, Shujun (2012) Design of low-loss 1-3 piezoelectric composites for high-power transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control 59:1969-75 |
| Lloyd, Eric E; Crossland, Randy F; Phillips, Sharon C et al. (2011) Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension 58:672-8 |
| Hartley, Craig J; Reddy, Anilkumar K; Madala, Sridhar et al. (2011) Doppler velocity measurements from large and small arteries of mice. Am J Physiol Heart Circ Physiol 301:H269-78 |
| Chintalgattu, Vishnu; Ai, Di; Langley, Robert R et al. (2010) Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 120:472-84 |
| Song, Liang; Maslov, Konstantin; Shung, K Kirk et al. (2010) Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo. J Biomed Opt 15:021303 |
| Zhang, Shujun; Lim, Jong Bong; Lee, Hyeong Jae et al. (2009) Characterization of hard piezoelectric lead-free ceramics. IEEE Trans Ultrason Ferroelectr Freq Control 56:1523-7 |
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