Tho objective of the project is to develop an accurate method for measuring blood flow using small, flat, disposable sensors that can be placed on or near the blood vessel. This new method of angle-independent Doppler velocity determination requires diffractive transducers, whose plane can be oriented parallel to the flow. Ultrasonic Doppler methods are now widely used in medicine for measuring and mapping blood flow. All high end ultrasonic scanners have Doppler and Doppler imaging capabilities. The problem with Doppler techniques is that the velocity extracted from Doppler shift is angle dependent and the angle is difficult to estimate. As a result, the error can be as large as 50%. This new method may offer a solution to this long standing problem. Diffractive transducers have been fabricated in the frequency range form 5 to 25 MHz range and used in conjunction with an instrument developed at Echocath for animal and patient studies. FEA simulation of transducer performance has also been carried out.?
| Reddy, Anilkumar K; Hartley, Craig J; Pham, Thuy T et al. (2014) Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci 69:152-9 |
| Gurha, Priyatansh; Wang, Tiannan; Larimore, Ashley H et al. (2013) microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One 8:e75882 |
| Crossland, Randy F; Durgan, David J; Lloyd, Eric E et al. (2013) A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol 305:R334-42 |
| Lee, Hyeong Jae; Zhang, Shujun (2012) Design of low-loss 1-3 piezoelectric composites for high-power transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control 59:1969-75 |
| Nagamani, Sandesh C S; Campeau, Philippe M; Shchelochkov, Oleg A et al. (2012) Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet 90:836-46 |
| Lloyd, Eric E; Crossland, Randy F; Phillips, Sharon C et al. (2011) Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension 58:672-8 |
| Hartley, Craig J; Reddy, Anilkumar K; Madala, Sridhar et al. (2011) Doppler velocity measurements from large and small arteries of mice. Am J Physiol Heart Circ Physiol 301:H269-78 |
| Chintalgattu, Vishnu; Ai, Di; Langley, Robert R et al. (2010) Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 120:472-84 |
| Song, Liang; Maslov, Konstantin; Shung, K Kirk et al. (2010) Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo. J Biomed Opt 15:021303 |
| Zhang, Shujun; Sherlock, Nevin P; Meyer, Richard J et al. (2009) Crystallographic dependence of loss in domain engineered relaxor-PT single crystals. Appl Phys Lett 94:162906 |
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