This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The high degree of organization of the nucleus suggests the existence of an underlying structural framework. The abundance, size and sequence motifs in the Nuclear Mitotic Apparatus protein (NuMA) make it a good candidate for a nuclear structural component. Identification of NuMA interacting partners is a key step in revealing a potential nuclear function.
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