This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIM-17is an abundant chromatin-associated protein that is required both for initiation of meiotic recombination and for the normal complement of histone modifications on sex chromosomes during meiotic prophase in C. elegans. HIM-17 is a modular protein containing of six copies of a large and highly degenerate but conserved motif that likely functions as a DNA binding module. To understand how HIM-17 serves as a molecular link between chromatin modification and meiotic double-strand break formation, we wish to identify the proteins that associate with HIM-17 in vivo using tandem mass spectrometry of immunoprecipitated protein complexes.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR011823-11
Application #
7420800
Study Section
Special Emphasis Panel (ZRG1-CB-H (40))
Project Start
2006-09-20
Project End
2007-08-31
Budget Start
2006-09-20
Budget End
2007-08-31
Support Year
11
Fiscal Year
2006
Total Cost
$2,859
Indirect Cost
Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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