This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is part of our structural genomics effort which aims to generate novel antibacterial compounds that will help to overcome the accelerating speed in which bacterial pathogens acquire resistance to common antibiotics, thus making these useless. We intend to solve co-structures of an essential bacterial protein in complex with several ligands to advance our in-house drug discovery effort on this protein. The resulting structures will be of high scientific interest since they promise to shed light on how to design inhibitors for a family of essential protein targets. Crystals for this protein are very small (< 60 microns) and do not diffract sufficiently on our in-house source, however data collected at the APS (Argonne National Lab) indicate that these crystals diffract sufficiently when exposed to synchrotron X-ray radiation.
Showing the most recent 10 out of 167 publications
