This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Proper control of transcriptional elongation is critical to the prevention of cancer. The expression of many genes is controlled at the level of elongation. This project is aimed at obtaining crystal structures of essential transcriptional elongation factors that are believed to function primarily in the maintanence of chromatin structure during transcription. Of particular interest is Spt6, which is believed to play a role in reassembling nucleosome structures after the elongating RNAPII complex has passed through a transcribed region. A related prokaryotic protein, Tex, is also being investigated. Relevant complexes of each of these structures will also be pursued.
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