Determine the neural networks involved in three aspects of nonverbal and social communication: affective prosody, perception of facial expression, and response to emotionally laden scenes. We examine each category of cognitive task from three levels to address the following questions. a. Perceptual: is the basic apparatus for visual and auditory perception of emotional, versus non-emotional, sensory information intact? b. affective; does perception of affect produce appropriate emotional arousal as evidenced by activation of emotion-mediated brain centers in the limbic circuit? c. executive: are the neural networks involved . in utilizing and making judgments about perceived and experienced affect intact? 2. Determine differences in these neural networks in higher functioning autistic individuals, which are specific to autism, in comparison to a non-autistic, language impaired population, along the following dimensions: a. regional dvsfunction: do autistic and control subjects differ in their ability to activate key brain regions associated with the above levels of processing? b. functional connectivity: do autistic and control subjects differ in the functional connections between critical brain regions, and how do these regions interact during task performance? c. anatomical underpinnings of specific symptons: can we identify regional and functional connectivity differences associated with specific symptoms of autism?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR013642-04S3
Application #
6597686
Study Section
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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